Carbapenems: Why MICs are important*
The higher the MIC, the shorter the time above MIC (T>MIC), which lowers the level of expected microbiological effect1
- The bactericidal activity of carbapenems is time dependent
- Time-dependent agents provide bactericidal activity during the period of time that free drug concentration remains above the MIC for target organisms1
Hypothetical carbapenem PK curve example*1
The longer free drug concentration remains above the MIC (T>MIC), the greater amount of time the drug is providing bactericidal activity.
Within the carbapenem class, T>MIC is the best predictor of bacterial killing.2-4
Lower MIC90 extends T>MIC to sustain bacterial killing within the dosing interval*1
For carbapenems with higher MICs, the time that the drug can provide bacterial killing is reduced.
Optimizing antimicrobial therapy via PK/PD principles—such as extending time
above MIC—is one strategy to potentially reduce antimicrobial resistance.2-4
Because the antipseudomonal carbapenems have similar PK profiles if dosed similarly, including protein-binding, lower MICs may help extend the
percentage of time above MIC.*1
*PK/PD data and in vitro activity do not necessarily correlate with clinical results; not intended to convey comparative safety or efficacy.